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[目的]了解深圳女性人群生殖道HPV感染与液基细胞学异常及宫颈上皮内瘤样病变间相关性。[方法]采取整群分层抽样的方法,在深圳市南山区沙河街道办事处辖区随机选择15～59岁智力正常的妇女为研究对象。研究对象1137例接受问卷调查、妇科检查、HPV检测、液基细胞学和阴道镜检查。[结果]研究人群HPV阳性率为14.0%,宫颈液基细胞学异常率13.6%,CIN现患率为4.4%。不同细胞学类型和不同病理类型的HPV阳性率有显著性差异(P<0.01),细胞学和病理学病变程度均与HPV滴度呈正相关(P<0.01)。[结论]随着HPV阳性率与病毒载量水平的增高,宫颈细胞学和组织学病变程度均加重。深圳妇女的宫颈病变尚处于发病的早期阶段,预防HPV感染至关重要。
[Objective] To understand the correlation between genital HPV infection and liquid-based cytology abnormalities and cervical intraepithelial neoplasia in female population in Shenzhen. [Methods] A stratified cluster sampling method was used to select 15 to 59-year-old women with normal intelligence randomly from the jurisdiction of Shahe Subdistrict Office in Nanshan District, Shenzhen. A total of 1137 subjects were surveyed by questionnaire, gynecological examination, HPV test, liquid-based cytology and colposcopy. [Results] The positive rate of HPV in study population was 14.0%, the abnormal rate of cervical liquid-based cytology was 13.6%, and the prevalence of CIN was 4.4%. The positive rate of HPV in different cytology types and pathological types was significantly different (P <0.01). The cytological and pathological lesions were positively correlated with HPV titer (P <0.01). [Conclusion] With the increase of HPV positive rate and viral load level, cervical cytology and histological lesions were aggravated. Shenzhen women’s cervical lesions are still in the early stages of disease, prevention of HPV infection is essential.