A whitening toothpaste containing pyrrolidone groups was developed. Through the stain-removal experiment on the hydroxyapatite discs with tobacco stains, the stain-removal abilities of ammonium acryloyldimethyltaurate/VP copolymer and its toothpaste were studied. The results showed that the new toothpaste containing pyrrolidone groups had good whitening effect. The new whitening toothpaste had good safety and it had no damage to the soft and hard tissues.