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目的:对甲磺酸帕珠沙星搽剂进行皮肤急性毒性试验、皮肤刺激性试验及皮肤过敏性试验,以考察其皮肤用药安全性。方法:将甲磺酸帕珠沙星搽剂涂抹于家兔背部完整或破损区脱毛皮肤,观察给药后动物局部皮肤红斑及水肿等急性毒性和刺激性情况。采用致敏与激发接触甲磺酸帕珠沙星搽剂,观察豚鼠过敏反应。结果:甲磺酸帕珠沙星搽剂对家兔完整或破损皮肤无明显局部毒性或局部刺激性。对豚鼠皮肤无过敏反应。结论:甲磺酸帕珠沙星搽剂短期皮肤用药是安全的。
Objective: Pazufloxacin mesylate on the skin acute toxicity test, skin irritation test and skin allergy test to examine the safety of the skin medication. Methods: Pazufloxacin mesylate smear on the back of intact or damaged area of hair removal of the skin, observed after administration of animal skin and other acute erythema and edema and other acute toxicity and irritation. Sensitized and challenged with the contact Pazufloxacin mesylate liniment to observe the guinea pig anaphylaxis. RESULTS: Pazufloxacin mesylate had no obvious local or local irritation on intact or damaged rabbits. No allergic reaction to guinea pig skin. Conclusion: Pazufloxacin mesylate is safe for short-term dermatological application.