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目的探讨内皮素(ET)及D-二聚体(D-D)在不同程度与阶段感染性腹泻患儿中的表达和临床意义。方法选取2012年6月~2014年12月该院收治的感染性腹泻患儿90例为研究组,根据病情分为重型组、中型组和轻型组,每组各30例。另选择健康婴幼儿30例为健康组。研究组在治疗前后抽血检测ET、D-D水平,并进行对比分析。结果治疗前,各组ET、D-D测定值比较,差异有统计学意义(P<0.05),ET、D-D值随腹泻程度加重而表达升高(P<0.01),其中以重型组升高最明显。重型组经治疗后ET、D-D较之治疗前明显下降(P<0.01)。ET与D-D间呈正相关(r=0.49,P=0.008)。结论重型腹泻患儿的血浆ET与D-D水平均明显上升,治疗后均明显降低。重型腹泻患儿血浆ET、D-D可以用来作为评估病情的重要指标,具有重要的临床应用价值。
Objective To investigate the expression and clinical significance of endothelin (ET) and D-dimer (D-D) in children with different stages and stages of infectious diarrhea. Methods Totally 90 children with infectious diarrhea admitted to our hospital from June 2012 to December 2014 were selected as the study group and divided into severe group, moderate group and light group according to the condition, 30 cases in each group. Another 30 healthy infants and young children for the health group. The study group before and after treatment blood test ET, D-D levels, and comparative analysis. Results Before treatment, the ET and DD values in each group were significantly different (P <0.05). The ET and DD values increased with the severity of diarrhea (P <0.01), especially in the severe group . The levels of ET and D-D in the severe group after treatment were significantly lower than those before treatment (P <0.01). There was a positive correlation between ET and D-D (r = 0.49, P = 0.008). Conclusion The levels of plasma ET and D-D in children with severe diarrhea were significantly increased after treatment, were significantly lower. The plasma ET, D-D in children with severe diarrhea can be used as an important index to evaluate the disease, which has important clinical value.