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先将羟丙基纤维基(HPC,平均分子量3×10~5,粒度190～460μ)与Carbopol 940(粒度2～6μ)以1:2磨碎混和。取不同量的心得安加入以上混合聚合物制成含主药10、15及20 mg的三种粘贴片,用9.5 mm冲模(0.71cm~2)于2×10~4N下压15秒钟,分别于pH 3.5及6.8二种缓冲液中研究其释放速率。实验结果说明药物从聚合物骨架中释放符合Nt/Na=Kt~n方程,即药物在t时间的释放与K及t~n成正比,K与系统结构及几何特性有关,n是扩散指数,非费克氏释放n值在0.5～1间,费克氏释放n=0.5,零级释放n=1。
Hydroxypropylcellulose (HPC, average molecular weight 3x10-5, particle size 190-460μ) was first ground in a 1: 2 ratio with Carbopol 940 (particle size 2-6μ). Take a different amount of propranolol into the above mixed polymer made of the main drug 10, 15 and 20 mg of three kinds of sticking tablets, with 9.5 mm die (0.71cm ~ 2) at 2x10 ~ 4N press for 15 seconds, The release rates were studied in pH 3.5 and 6.8 respectively. The experimental results show that the release of the drug from the polymer skeleton is in accordance with the Nt / Na = Kt ~ n equation, that is, the release of the drug at time t is proportional to K and t ~ n, K is related to the system structure and geometric properties, n is the diffusion index, Non-Fick’s release n value of 0.5 to 1, Feke’s release n = 0.5, zero-order release n = 1.