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目的探讨预防性应用抗生素对肝硬化上消化道出血患者感染的影响。方法选取肝硬化上消化道出血患者110例,将患者随机分为对照组与观察组。对照组患者给予常规治疗,观察组患者在对照组常规治疗基础上预防性应用抗生素进行治疗,分析比较两组患者在住院期间治疗效果、再出血状况、感染率、死亡率以及治疗后是否出现不良反应。结果经治疗发现,预防性应用抗生素的观察组患者肝硬化上消化道再出血几率仅为18.18%,低于对照组患者的38.18%(P<0.05);并且对比两组患者治疗后感染情况,观察组总感染率为34.54%,优于对照组的54.54%(P<0.05)。结论预防性应用抗生素能够有效抑制肝硬化上消化道出血患者感染情况,在一定程度上保障了患者的生命安全,值得临床推广。
Objective To investigate the effect of prophylactic antibiotics on patients with cirrhosis and upper gastrointestinal bleeding. Methods 110 patients with cirrhosis and upper gastrointestinal hemorrhage were selected and randomly divided into control group and observation group. The patients in the control group were given routine treatment. The patients in the observation group were treated with prophylactic antibiotics on the basis of conventional treatment. The treatment effect, rebleeding status, infection rate, mortality and post-treatment adverse events were compared between the two groups reaction. Results After treatment, the rate of upper gastrointestinal rebleeding in cirrhosis was only 18.18% in the observation group with prophylactic antibiotics, which was lower than that in the control group (38.18%) (P <0.05). After comparing the two groups of patients after treatment, The total infection rate in observation group was 34.54%, which was better than that in control group (54.54%, P <0.05). Conclusion The prophylactic use of antibiotics can effectively inhibit the infection of cirrhotic patients with upper gastrointestinal bleeding, to a certain extent, protect the patient’s life safety, worthy of clinical promotion.