论文部分内容阅读
目的:观察采用自拟活血化瘀方联合前列地尔治疗2型糖尿病(T2DM)下肢血管病变患者的临床疗效。方法:河北省中医院2012年4月~2014年6月收治的120例确诊为T2DM并下肢血管病变患者,采用随机数字表法分为观察组和对照组各60例,两组患者均给予常规治疗及前列地尔治疗,观察组加用自拟活血化瘀方进行下肢浸泡治疗,对照组予温水浸泡。观察两组患者临床疗效差异。结果:治疗后,两组患者全血黏度高切、全血黏度低切、血浆黏度、红细胞压积较治疗前均显著降低(P<0.05),观察组疗效更佳(P<0.05);两组患者患肢足背动脉血流量、踝/肱动脉血压比值、血流动力学指标均较治疗前显著升高(P<0.05),观察组疗效更佳(P<0.05);两组患者血清CRP、IL-6、TNF-α水平较治疗前均显著降低(P<0.05),观察组疗效更佳(P<0.05);观察组治疗总有效率(93.33%)显著高于对照组(73.33%)(P<0.05)。结论:活血化瘀方联合前列地尔治疗T2DM下肢血管病变患者能进一步改善患者的血流动力学、血液流变学指标,提高临床疗效。
Objective: To observe the curative effect of treating patients with lower extremity vascular disease of type 2 diabetes mellitus (T2DM) by self-made activating blood circulation and removing blood stasis prescription combined alprostadil. Methods: One hundred and twenty patients with T2DM and lower extremity vascular disease who were admitted to Hebei Provincial Hospital of Traditional Chinese Medicine from April 2012 to June 2014 were randomly divided into observation group (60 cases) and control group (60 cases). Both groups were given routine Treatment and alprostadil treatment, the observation group plus own blood circulation to the lower limb immersion treatment, the control group to warm water soak. The difference of clinical efficacy between the two groups was observed. Results: After the treatment, the whole blood viscosity, the low blood viscosity, the plasma viscosity and the hematocrit in both groups were significantly lower than those before treatment (P <0.05), and the effect in the observation group was better (P <0.05); The blood flow of the dorsal limbs, the ratio of ankle / brachial artery blood pressure and the hemodynamics in the limbs of the patients were significantly higher than those before treatment (P <0.05), and the effects of the observation group were better (P <0.05) The levels of CRP, IL-6 and TNF-α in the observation group were significantly lower than those in the control group (P <0.05), and the observation group had better effect (P <0.05). The total effective rate of the observation group was significantly higher than that of the control group (93.33% %) (P <0.05). Conclusion: Huoxue Huayu decoction combined with alprostadil treatment of T2DM lower extremity vascular disease patients can further improve the patient’s hemodynamics, hemorheology, and improve clinical efficacy.