目的:考察生长抑素微泵持续给药的稳定性,为临床合理用药提供依据。方法:模拟临床给药方式,将生长抑素分别与0.9%氯化钠注射液、5%葡萄糖注射液配伍,于25℃和37℃在给药后0,1,2,3,4,5,6,8,10,12h时取样,高效液相色谱法测定生长抑素的相对百分含量,同时观察配伍液外观和pH变化,并比较输液泵常规使用和避光使用时配伍液含量、外观的变化。结果:与0.9%氯化钠注射液配伍时,生长抑素注射液在25℃时8h内是稳定的,37℃时生长抑素在5h内稳定;与5%葡萄糖注射液配伍时,生长抑素注射液在25℃时8h内是稳定的,37℃时生长抑素在4h内稳定。光线对生长抑素的含量有一定影响。结论:临床上在微泵给予生长抑素时应合理控制维持时间并注意避光。 Objective: To investigate the stability of somatostatin micro-pump for sustained administration and provide the basis for clinical rational drug use. Methods: To simulate the clinical mode of administration, somatostatin was respectively matched with 0.9% sodium chloride injection and 5% glucose injection at 0, 1, 2, 3, 4, 5 , 6, 8, 10, 12h sampling, HPLC determination of the relative percentage of somatostatin, while observing the compatibility of the appearance and pH changes, and compare the infusion pump routine use and dark when the compatibility of liquid content, Changes in appearance. Results: When combined with 0.9% sodium chloride injection, somatostatin injection was stable within 8 hours at 25 ℃ and somatostatin was stable within 5 hours at 37 ℃. When matched with 5% glucose injection, the growth inhibition Su injection at 25 ℃ within 8h is stable, somatostatin at 37 ℃ stable within 4h. Light on somatostatin content has a certain impact. Conclusion: In the clinical administration of somatostatin by micropump, the maintenance time should be rationally controlled and avoid light.