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金属离子(特别是锌、铜和铁)在神经生物学中的作用越来越引起人们的关注。最近的研究报道了锌和铜在谷氨酸能神经突触中的释放以及对N-甲基-D-天冬氨酸(N-Methyl-D-aspartate,NMDA)受体的影响,强调了突触的无机微环境和神经科学之间的密切关联性。此外,大部分的神经退行性病变,包括阿尔茨海默病和帕金森病也以组织中铁离子含量的升高和铜、锌的错误定位为特征(例如淀粉样蛋白的累积)。愈来愈多的以纠正这些金属的非正常状态,避免这些必需矿物质系统紊乱为目标的药用化学治疗正在试验研究中。这些小分子物质在疾病的治疗中表现出至关重要的作用。
The role of metal ions (especially zinc, copper and iron) in neurobiology has drawn increasing attention. Recent studies have reported the release of zinc and copper in glutamatergic synapses as well as the effects on N-Methyl-D-aspartate (NMDA) receptors, emphasizing The close association between the synaptic inorganic microenvironment and neuroscience. In addition, most neurodegenerative diseases, including Alzheimer’s disease and Parkinson’s disease, are also characterized by elevated iron levels in the tissues and erroneous localization of copper and zinc (eg, amyloid accumulation). A growing number of medicinal chemotherapies aimed at correcting the abnormal status of these metals and averting these essential mineral system disorders are undergoing experimental studies. These small molecules show a crucial role in the treatment of diseases.