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目的:探讨子宫颈局部应用红色诺卡氏菌细胞壁骨架制剂(Nocardia Rubra Cell Wall Skeleton,Nr-CWS)治疗人乳头状瘤病毒(human papilloma virus,HPV)亚临床感染的临床疗效。方法:采用双盲随机对照试验设计,将感染HPV患者随机分为治疗组18例,对照组10例,分别使用Nr-CWS和赋形剂。在治疗后4个月、8个月共2次于月经干净后3~10天对患者进行HPV检测,分析Nr-CWS对生殖道HPV感染的清除效果。结果:4个月后HPV检测示治疗组HPV感染转阴率为66.67%,与对照组20.00%比较差异有统计学意义(P<0.05);8个月后HPV检测示治疗组HPV感染转阴率为77.78%,与对照组30.00%比较差异有统计学意义(P<0.05)。结论:Nr-CWS对女性下生殖道HPV有良好的清除作用,对子宫颈HPV亚临床感染有疗效明确的治疗作用。
Objective: To investigate the clinical efficacy of cervical topical application of Nocardia Rubra Cell Wall Skeleton (Nr-CWS) in the treatment of sub-clinical infection of human papilloma virus (HPV). Methods: A double-blind, randomized, controlled trial was designed. HPV-infected patients were randomly divided into treatment group (18 cases) and control group (n = 10). Nr-CWS and vehicle were used respectively. In the 4 months after treatment, 2 times in 8 months after the menstrual clean 3 to 10 days for HPV testing in patients with Nr-CWS on genital tract HPV infection clearance effect. Results: After 4 months of HPV testing, the negative rate of HPV infection in the treatment group was 66.67%, which was significantly different from that in the control group (20.00%, P <0.05). After 8 months of HPV testing, the HPV infection in the treatment group was negative The rate was 77.78%, which was significantly different from that of control group 30.00% (P <0.05). CONCLUSION: Nr-CWS has a good scavenging effect on female genital HPV and has a definite curative effect on cervical HPV subclinical infection.