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目的报告1例因接种第3剂吸附无细胞百白破联合疫苗致大疱型多形红斑病例。方法按照预防接种异常反应调查规范对1例接种第3剂吸附无细胞百白破联合疫苗后出现大疱型多形红斑病例开展调查,组织诊断。结果根据饮食、用药情况排除食物或药物过敏;接种操作流程符合技术规范,排除实施差错;同批次疫苗接种均未发现类似病例,排除疫苗质量问题。接种疫苗10 h后在接种部位发现红点,增大红斑,出现水疱,在时间上存在关联;经县级疑似预防接种异常反应调查专家组诊断,确诊为大疱型多形红斑。结论该病例是接种吸附无细胞百白破联合疫苗后出现大疱型多形红斑,属于预防接种异常反应。
Objective To report a case of bullous erythema multiforme caused by inoculation of the third dose of cell-free diphtheria combination vaccine. Methods A case of bullous erythema multiforme erythema was investigated in one case after inoculation of the third dose of combined cell-free baicalin-baicalin vaccine in accordance with the investigation of abnormal immune response to vaccination. Results According to the diet and drug usage, food or drug allergy was excluded. The inoculation procedure complied with the technical specification and the implementation error was eliminated. No similar cases were found in the same batch vaccination, and the vaccine quality was excluded. After 10 hours of vaccination, the red spots were found in the inoculation site, the erythema increased and blisters appeared. There was a correlation in time. The diagnosis was made by the expert panel of the county-level suspected vaccination abnormal reaction investigation team and was diagnosed as bullous erythema multiforme. Conclusion This case is bullous erythema multiforme after inoculation of cell-free baibutong combination vaccine, belonging to the abnormal reaction of vaccination.