瘙痒是原发性胆汁性肝硬化(PBC)和其他各种慢性胆汁郁积患者难以忍受的症状。文献报道有用消胆胺、苯巴比妥、皮质激素等治疗,但效果不满意。瘙痒的原因仍不明,与胆汁酸潴留的关系也未确定。本文作者提出一种假设,即肝内高浓度胆汁酸损伤肝细胞膜后,导致肝脏释放一种尚未确定的致痒因子,因此引起瘙 Pruritus is an unbearable symptom of patients with primary biliary cirrhosis (PBC) and various other forms of chronic cholestasis. The literature reported useful cholestyramine, phenobarbital, corticosteroids and other treatment, but the effect is not satisfied. The cause of itching is still unknown, and the relationship between bile acid retention has not been determined. The authors propose the hypothesis that a high concentration of intrahepatic bile acids damage the liver cell membrane, causing the liver to release an indeterminate cause of itching, causing itching