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由磺胺嘧啶(SD)、磺胺噻唑(ST)、磺胺二甲嘧啶(SM_2)各0.167g 压制成的片剂(简称三磺片),或由上述三种药各取3.3%的量配成的10%的混悬剂(简称三磺混悬剂),其作用文献上说法不一。有的认为“各磺胺药的总效应是相加的”(上海第一医学院主编:医用药理学,第1版,23页,人民卫生出版社,1977年),有的资料则介绍说,三磺合用,“作用较单纯应用为强,吸收亦较快,而且对肾脏的副作用较小,溶解度且大,不易形成尿路结石,可以不用同服碳酸氢钠”(广西百色地区卫生局等:医药卫生人员业务复习题参考答案(药学分册),55页,1979)。还有的认为,ST“乙酰化率高,其乙酰化物的溶解度很低,排泄时容易在肾小管析出结晶,形成结石,……,因此服药期间应多喝水(每日应喝1500ml 以上),并与等量碳酸氢钠同服,使尿呈碱性,以增加药物在尿内的溶解度,减少结晶的析出。也可改用多种磺胺合剂(如三磺片)以达到这一目的。”(陈新谦主编:新编药物学,第10版,79页,人民卫生出版社,1974)
The tablets (abbreviated as tri-sulfosuccinate tablets) compacted from 0.167g each of SD, Sulfadiazine (ST) and Sulfadimethoxine (SM_2) or 3.3% of the above three drugs 10% of the suspension (referred to as the three-sulfonamide suspension), the role of the literature on different opinions. Some think that “the total effect of each sulfa drug is additive ” (Shanghai First Medical College Editor: Medical Pharmacology, 1st Edition, 23 pages, People’s Health Publishing House, 1977), and some information is introduced Said that the use of three sulfonated, “effect than the simple application as strong, absorption is also faster, and the side effects of the smaller kidney, solubility and large, not easy to form urinary tract stones, you can not serve with sodium bicarbonate Regional Health Department: medical and health personnel business review reference answer (Pharmacy Volume), 55 pages, 1979). Some believe that ST ”acetylation rate is high, the solubility of acetylation is very low, excretion of renal tubular easily precipitate crystallization, the formation of stones, ... ... Therefore, medication should drink plenty of water (drink 1500ml or more daily ), And with the same amount of sodium bicarbonate with the same, the urine was alkaline, in order to increase the solubility of drugs in the urine, reduce the crystallization of precipitation. Can also use a variety of sulfonamides (such as tri-sulfonium) to achieve this Purpose. “” (Chen Xinqian editor: New Pharmacology, 10th Edition, 79 pages, People’s Medical Publishing House, 1974)