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目的:观察美托洛尔治疗扩张型心肌病慢性心力衰竭的临床疗效。方法:42例扩张型心肌病慢性心力衰竭患者随机分成2组,对照组(21例)行常规治疗,治疗组(21例)在常规治疗的基础上加用美托洛尔并逐步加大剂量至靶剂量,疗程均为24周。疗程结束时观察2组疗效及左心室舒张末内径、左心室收缩末内径、左心室射血分数的变化。结果:治疗24周与治疗前比较,治疗组患者左心室舒张末内径、左心室收缩末内径明显缩小,左心室射血分数增加,差异有统计学意义(P<0.01),治疗总有效率治疗组优于对照组,差异有统计学意义(P<0.05)。结论:扩张型心肌病慢性心力衰竭患者应用美托洛尔治疗,能够改善心功能,提高生活质量。
Objective: To observe the clinical efficacy of metoprolol in the treatment of dilated cardiomyopathy patients with chronic heart failure. Methods: Forty-two patients with chronic heart failure with dilated cardiomyopathy were randomly divided into two groups. The control group (n = 21) received routine treatment. The treatment group (n = 21) received metoprolol The target dose, treatment are 24 weeks. At the end of treatment, the curative effect of two groups and the changes of left ventricular end-diastolic diameter, left ventricular end-systolic diameter and left ventricular ejection fraction were observed. Results: After treatment for 24 weeks, the left ventricular end-diastolic diameter, left ventricular end-systolic diameter and the left ventricular ejection fraction increased significantly in treatment group compared with those before treatment (P <0.01). The total effective rate of treatment Group than the control group, the difference was statistically significant (P <0.05). Conclusion: Metoprolol treatment in patients with dilated cardiomyopathy chronic heart failure can improve cardiac function and improve quality of life.