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目的 探讨冠状动脉病变积分 (CAS)与脉压指数 (PPI)的关系。方法 711例行冠状动脉造影者 ,其中男 4 70例 ,女 2 4 1例 ,年龄 30～ 82 (6 1± 8)岁。以标准Judkins法行冠状动脉造影术 ,计算机定量分析系统 (QCA)分析冠状动脉狭窄程度并计算CAS。标准台式水银血压计测定外周肱动脉收缩压 (SBP)和舒张压 (DBP) ,并计算脉压 (PP)及PPI。结果 年龄、性别、体重指数、SBP、PP、PPI、升主动脉根径 (Ao)、高血压病史、2型糖尿病病史、高密度脂蛋白胆固醇均与CAS有显著相关关系。经多因素Logistic回归分析显示 ,PPI和Ao这两个指标与CAS呈显著正相关 (β =0 0 4 1～ 0 14 9,P均为0 0 0 0 )。结论 PPI和Ao这两个指标与CAS密切相关 ,是冠心病发生发展的良好的预测指标 ,并可应用于临床指导冠心病危险人群的早期干预。
Objective To investigate the relationship between coronary artery disease score (CAS) and pulse pressure index (PPI). Methods 711 routine coronary angiography, of which 4 70 were males and 2 141 females, aged 30 to 82 (6 1 8) years of age. The standard Judkins method of coronary angiography, computerized quantitative analysis system (QCA) analysis of coronary artery stenosis and calculate CAS. Peripheral brachial artery systolic pressure (SBP) and diastolic pressure (DBP) were measured by a standard bench-top mercury sphygmomanometer. Pulse pressure (PP) and PPI were calculated. Results Age, sex, body mass index, SBP, PP, PPI, ascending aortic root diameter (Ao), history of hypertension, history of type 2 diabetes and high density lipoprotein cholesterol were all significantly correlated with CAS. Logistic regression analysis showed that PPI and Ao had significant positive correlation with CAS (β = 0 0 4 1 ~ 0 14 9, P 0 0 0 0). Conclusion The two indexes of PPI and Ao are closely related to CAS, which is a good predictor of the development of coronary heart disease and can be applied to the early intervention of clinically guiding the risk of coronary heart disease.