目的 通过对鼻敏合剂的毒理学研究,为临床安全用药提供客观依据。方法 实施小鼠急性毒性实验（半数致死量、最小致死量、最大耐受量）,小鼠骨髓细胞染色体畸变实验,小鼠骨髓细胞微核实验。结果 鼻敏合剂对小鼠的最小致死量>68g/kg;亚急性染毒未引起染色体畸变率和微核率升高。结论 服用鼻敏合剂是安全的。 Objective To provide an objective basis for clinical safe drug use through the toxicology study of nasal sensitizer. Methods The mice were tested for acute toxicity (half lethal dose, minimum lethal dose, and maximum tolerated dose), chromosome aberration test of mouse bone marrow cells, and micronucleus test of mouse bone marrow cells. Results The minimum lethal dose of nasal sensitizer in mice was> 68g/kg; subacute exposure did not cause chromosome aberration rate and micronucleus rate to increase. Conclusion Taking nasal sensitization mixture is safe.