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目的研究来氟米特联合糖皮质激素治疗难治性肾病综合征的疗效、安全性和副反应。方法48例难治性肾病综合征患者,应用来氟米特联合糖皮质激素治疗6个月,用药期间观察尿蛋白定量、血清白蛋白、肾功能、胆固醇以及不良反应,6个月后行疗效和安全性的评价。结果来氟米特联合糖皮质激素(治疗组)治疗难治性肾病综合征尿蛋白缓解率为75%,高于环磷酰胺冲击(对照组)治疗的缓解率62.5%。结论来氟米特联合糖皮质激素治疗对难治性肾病综合征效果好且副作用轻,耐受性好。
Objective To study the efficacy, safety and side effects of leflunomide and glucocorticoid in the treatment of refractory nephrotic syndrome. Methods Forty-eight patients with refractory nephrotic syndrome were treated with leflunomide combined with glucocorticoid for 6 months. Urinary protein, serum albumin, renal function, cholesterol and adverse reactions were observed during the treatment period. The curative effect was observed after 6 months And safety evaluation. Results Leflunomide combined with glucocorticoid (treatment group) treatment of refractory nephrotic syndrome urine protein remission rate was 75%, higher than the cyclophosphamide shock (control group) treatment remission rate of 62.5%. Conclusion Leflunomide combined with glucocorticoid treatment is effective in refractory nephrotic syndrome with mild side effects and good tolerability.