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目的:观察加减生脉陷胸汤治疗病毒性心肌炎(viral myocarditis,VMC)的临床疗效及其对cTnⅠ、免疫功能的影响.方法:60例病毒性心肌炎患者随机分为中药组(30例)和西药组(30例),中药组给予加减生脉陷胸汤治疗,西药组用西药常规治疗.分别观察两组患者治疗前和治疗1个疗程后的临床疗效、心肌钙蛋白Ⅰ及T淋巴细胞亚群的变化.同时选20例健康献血者为正常组检测心肌钙蛋白Ⅰ及T淋巴细胞亚群.结果:治疗前,患者的心肌钙蛋白Ⅰ含量均高于正常组(P＜0.01),CD4+、CD8+、CD4+/CD8+均低于正常组(P＜0.01).治疗1个疗程后,中药组和西药组心肌钙蛋白Ⅰ含量均明显下降(P＜0.01),CD4+、CD8+、CD4 +/CD8+明显高于治疗前(P＜0.01,P＜0.05);但中药组cTnⅠ含量明显低于西药组(P＜0.01),CD4+、CD8+、CD4+/CD8+明显高于西药组治疗后(P＜0.05);中药组有效率高于西药组(P＜0.05).结论:加减生脉陷胸汤能提高治疗VMC的疗效,同时能保护心肌,调节T淋巴细胞亚群.“,”Objective:To investigate the therapeutic effects of Modified Pulse-Engendering and Chest-Draining Decoction on cTnl and immunity of patients with viral myocarditis (VMC).Methods:Totally 60 patients with VMC were randomly divided into Chinese medicine group and western medicine group,30 cases in each group.Chinese medicine group were given Modified Pulse-Engendering and Chest-Draining Decoction while western medicine group were given conventional treatment with western medicine.The clinical effects and changes of cTnⅠ and T lymphocyte subsets after one treatment course in both groups were observed.Twenty healthy blood donators were selected to determine their normal level of myocardial calcium protein Ⅰ and T lymphocyte subsets.Results:Before treatment,the content of cTnⅠ was higher than that in normal group (P ＜ 0.01);the levels of CD4 +,CD8 + and CD4 + / CD8 + were lower than those in the normal group.After one treatment course,the contents of cTnⅠ in both groups declined obviously (P ＜0.01).The levels of CD4 +,CD8 + and CD4 +/ CD8 + in both groups were higher than those before treatment (P ＜ 0.05,P ＜ 0.01).The content of cTnl in Chinese medicine group was markedly lower than that in western medicine group (P ＜ 0.01).The effective rate in Chinese medicine group was apparently higher than that in the western medicine group (P ＜0.05).Conclusion:Modified Pulse-Engendering and Chest-Draining Decoction can improve the effective rate on VMC,protect the myocardium and regulate T lymphocvte subsets in VMC patients.