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作者用灵长类树鼩,在建立了人乙型肝炎病毒(HHBV)感染的动物模型基础上,研究HHBV感染与原发性肝癌(PLC)发生的病因学关系及其对黄曲霉毒素B_1(AFB_1)诱发PLC的影响. 实验树鼩80只,其中58只先接种HHBV,用血凝法、放免法和分子杂交等技术检测血清HHBV感染标志.6周后将已感染HHBV〔HHBV(+)〕和未感染者〔HHBV(-)〕各分为两个亚组:一组给予口服AFB_1,另一组不给.AFB1剂量为200～400ng/
Using primate tree shrews, the authors established an animal model of human hepatitis B virus (HHBV) infection to study the etiology of HHBV infection and primary liver cancer (PLC) and its effect on aflatoxin B_1 ( AFB_1) Induced the effects of PLC. Eighty experimental animals, of which 58 were vaccinated with HHBV first, were tested for serum HHBV infection using hemagglutination, radioimmunoassay, and molecular hybridization techniques. HHBV infection was detected 6 weeks later (HHBV(+) ] and non-infected individuals (HHBV(-)) were divided into two subgroups: one group was given oral AFB_1, the other group was not given. AFB1 dose was 200-400 ng/