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目的:观察多西紫杉醇(DOC)联合奥沙利铂(L-OHP)和5-氟尿嘧啶(5-Fu)的DOF方案治疗晚期胃癌的临床疗效和不良反应。方法:化疗方案DOC 75 mg/m2(第1天),L-OHP 130 mg/m2(第1天),5-Fu 2.5 g/m2,持续静脉滴注120 h,21 d为1个周期,至少应用2个周期,进行疗效评价并评估反应。结果:全组73例均可评价疗效,总有效率为68.5%,其中完全缓解(CR)18例(24.7%),部分缓解(PR)32例(43.8%),至肿瘤进展时间为9.2个月,中位生存期为13.7个月。初治的46例有效率为76.1%,复治的27例有效率为55.5%。主要不良反应为骨髓抑制、口腔黏膜炎和周围神经毒性反应,其中Ⅲ～Ⅳ度白细胞下降率为26.0%,无治疗相关性死亡。结论:DOF方案是晚期胃癌的有效化疗方案,不良反应易于耐受。
Objective: To observe the clinical efficacy and side effects of docetaxel (DOC) combined with DOF regimen of oxaliplatin (L-OHP) and 5-fluorouracil (5-Fu) in the treatment of advanced gastric cancer. Methods: The duration of chemotherapy was DOC 75 mg / m2 (day 1), L-OHP 130 mg / m2 (day 1) and 5-Fu 2.5 g / m2. Apply at least 2 cycles to evaluate efficacy and evaluate response. Results: The efficacy of the whole group was evaluated in 73 cases, with a total effective rate of 68.5%. Among them, 18 cases (24.7%) had complete remission (CR), 32 cases (43.8%) had partial remission (PR) Month, the median survival was 13.7 months. The initial effective rate of 46 cases was 76.1%, 27 cases of retreatment effective rate was 55.5%. The main adverse reactions were myelosuppression, oral mucositis and peripheral neurotoxicity, in which grade Ⅲ ~ Ⅳ leukopenia was 26.0%, and no treatment-related death occurred. Conclusion: DOF regimen is an effective chemotherapy regimen for advanced gastric cancer, with adverse reactions easily tolerated.