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目的:探讨大鼠口服不同剂量雄黄后砷的药动学及毒代动力学规律。方法:氢化物发生-原子荧光光谱法测定大鼠单次灌胃3.5 g·kg~(-1)和7.0 g·kg~(-1)雄黄后不同时间的血及组织中砷含量,拟合药动学模型,计算药动学参数。结果:大鼠单次口服雄黄后砷的药动学特征符合一室模型,3.5g·kg~(-1)和7.0 g·kg~(-1)两个剂量组主要药动学和毒代动力学参数分别为:t_(1/2):15.87h和16.87 h;C_(max):3.74×10~2μg·L~(-1)和6.89×10~2μg·L~(-1);AUC_(0-6):9.86×10~3μg·h·L~(-1)和1.69×10~4μg·h·L~(-1)。砷在各组织均有分布,以肝、肾中含量最高。结论:大鼠口服不同剂量雄黄后砷在大鼠血中的药动学过程基本一致,在体内可造成蓄积。
Objective: To investigate the pharmacokinetics and pharmacokinetics of arsenic in rats after oral administration of different doses of realgar. Methods: The levels of arsenic in blood and tissues at different time points were measured by hydride generation - atomic fluorescence spectrometry (FACS) at a dose of 3.5 g · kg -1 and 7.0 g · kg -1, Pharmacokinetic model to calculate pharmacokinetic parameters. Results: The pharmacokinetics of arsenic in rats after single oral administration of realgar fit the one-compartment model. The pharmacokinetics and toxicity of arsenic in 3.5g · kg -1 and 7.0g · kg -1 groups The kinetic parameters were as follows: t 1/2: 15.87h and 16.87 h; C max: 3.74 × 10-2μg · L -1 and 6.89 × 10-2μg · L -1; AUC_ (0-6): 9.86 × 10 ~ 3μg · h · L -1 and 1.69 × 10 ~ 4μg · h · L -1, respectively. Arsenic in all organizations are distributed to the liver, kidney, the highest content. Conclusion: The pharmacokinetics of arsenic in rat blood after oral administration of different doses of realgar is basically the same, which can cause accumulation in the body.