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目的 :总结头颈部Castleman病(Castleman’s disease,CD)的临床病理表现、诊断、治疗及预后特点。方法 :对1998年1月—2015年9月就诊于第二军医大学附属长征医院口腔科的10例CD患者的临床资料进行回顾分析,对组织病理切片进行光镜观察和免疫组织化学检测。结果:10例患者中,男6例、女4例,中位年龄44岁(19~67岁);就诊前病程15 d~8 a不等(中位病程12个月);位于腮腺3例、颈部7例;按组织病理分型,透明血管型6例,浆细胞型4例;按临床类型分类,局限性透明血管型CD 6例、局限性浆细胞型CD 2例、多中心CD 2例。结论:CD应作为头颈部肿块的鉴别对象。无论是透明血管型CD,还是浆细胞型CD,明确诊断后均应作长期观察,以及时发现疾病复发、恶变征兆。
Objective: To summarize the clinicopathological features, diagnosis, treatment and prognosis of Castleman’s disease (CD) in the head and neck. Methods: The clinical data of 10 patients with CD from the Department of Stomatology, Changzheng Hospital affiliated to Second Military Medical University from January 1998 to September 2015 were retrospectively analyzed. The histopathological sections were examined by light microscopy and immunohistochemistry. Results: Among the 10 patients, 6 were males and 4 were females, with a median age of 44 years (ranging from 19 to 67 years). The duration of pre-treatment ranged from 15 days to 8 years (median duration was 12 months) , Neck 7 cases; according to histopathological classification, 6 cases of clear blood vessel type and 4 cases of plasma cell type. According to the clinical classification, there were 6 cases of localized clear blood vessel type CD, 2 cases of localized plasma cell type CD, 2 cases. Conclusion: CD should be used as the identification of head and neck mass. Whether it is transparent vascular CD, or plasma cell CD, after a clear diagnosis should be long-term observation, and timely detection of disease recurrence, signs of malignancy.