丙戊酸钠(Sodium Valproate、VPA,抗癫灵)是治疗癫痫的高效能病物。其副作用一般仅有胃肠不适,偶有食欲亢进、胰腺炎,毛发稀疏,血清转氨酶升高、Fanconi综合征、高氨基酸尿等。急性间质性肾炎可继发于细菌感染,某些药物如二甲氧苯青霉素和其它青霉素相关药等。本文首次报道1例VPA诱发的间质性肾炎,并探讨其与多种免疫学因素之间的相互关系。 Sodium Valproate (VPA, anti-epileptic) is a highly potent drug for the treatment of epilepsy. The side effects are generally only gastrointestinal discomfort, occasional appetite hyperactivity, pancreatitis, hair thinning, elevated serum transaminases, Fanconi syndrome, high amino aciduria and so on. Acute interstitial nephritis secondary to bacterial infection, some drugs such as methicillin and other penicillin-related drugs. In this paper, we report the first case of VPA-induced interstitial nephritis, and explore its relationship with a variety of immunological factors.