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目的:研究降压宝蓝片对自发性高血压大鼠(SHR)左心室肥厚的影响。方法:将12周龄雄性SHR随机分为SHR组(0.5%CMC-Na),降压宝蓝片组(0.6 g·kg-1),依那普利组(0.02 g·kg-1),另设同龄正常血压的Wistar-kyoto(WKY)大鼠10只为正常组(0.5%CMC-Na),ig给药,连续12周。大鼠尾动脉血压计测定大鼠尾动脉收缩压(SBP),舒张压(DBP),平均动脉压(MAP)。超声心动图分别测量左室后壁厚度(LVPWT),室间隔厚度(IVST),左室舒张末内径(LVEDD),左心室收缩末内径(LVESD)及RR间期,计算左心室短轴缩短率(LVFS),左心室收缩末期容积(LVESV),左心室舒张末期容积(LVEDV),射血分数(LVEF)和每搏量(SV)。取全心及左心室称重,计算心脏指数(CI)和左心室指数(LVMI)。左室心肌组织HE染色,病理图像分析系统进行心肌细胞横径(CTD)测量和形态学观察。结果:与正常组比较,SHR组SBP,DBP和MBP显著升高(P<0.01),LVEDV,LVESV和SV均明显降低(P<0.01),CI,LVMI和CTD明显增加(P<0.01),LVST,LVPWT,LVFS,LVEF有所增加,但无统计学意义;与模型组比较,降压宝蓝片能显著降低LVFS,LVEF,CI,LVMI和CTD(P<0.05),明显改善左室心肌组织病理学改变;对血压有一定的降压作用,但降压幅度明显低于依那普利,且与SHR对照组比较无显著性差异。结论:降压宝蓝片具有改善高血压心肌肥厚的作用。
Objective: To study the effect of DBP on left ventricular hypertrophy in spontaneously hypertensive rats (SHR). Methods: SHR (0.5% CMC-Na), SHG (0.6 g · kg-1), enalapril (0.02 g · kg-1) Ten Wistar-kyoto (WKY) rats with normotensive normotensive rats were given normal saline (0.5% CMC-Na) for ig administration for 12 weeks. The rat tail artery sphygmomanometer was used to measure SBP, DBP and MAP of the tail artery in rats. The left ventricular posterior wall thickness (LVPWT), interventricular septum thickness (IVST), left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD) and RR interval were measured by echocardiography. LVFS, LVESV, LVEDV, LVEF and SV. Take the whole heart and left ventricular weight, calculate the cardiac index (CI) and left ventricular index (LVMI). Left ventricular myocardial tissue HE staining, pathological image analysis system for measurement of myocardial cell diameter (CTD) and morphological observation. Results: Compared with normal group, SBP, DBP and MBP in SHR group were significantly increased (P <0.01), LVEDV, LVESV and SV were significantly decreased (P <0.01), CI, LVMI and CTD were significantly increased LVST, LVPWT, LVFS and LVEF increased, but there was no statistical significance. Compared with model group, DBP could significantly decrease LVFS, LVEF, CI, LVMI and CTD (P <0.05) and significantly improve left ventricular myocardial tissue Pathological changes; blood pressure has a certain antihypertensive effect, but the amplitude was significantly lower than enalapril, and SHR control group no significant difference. Conclusion: DBP has the effect of improving myocardial hypertrophy in hypertension.