论文部分内容阅读
控缓释制剂是创新药物的重要来源,但由于中药成分复杂,理化性质体现表观性等一系列关键问题尚未完全廓清,故真正成熟上市、能体现中药精髓的复方控缓释制剂基本没有,限制了中药控缓释制剂的研发。结合中药复方用药多成分协同作用的特点,通过对中药复方控缓释制剂制备过程中的一系列瓶颈问题的分析,结合多成分“整体受控、同步溶蚀”的中药控缓释制剂制备指导原则,在前期利用超分子化学诠释中医药理论的基础上,借鉴单成分精确控制技术,运用超分子化学理论,系统探讨中药缓控释制剂多成分整体受控的超分子机制,阐明中药复方多成分体系中超分子体存在所带来的影响,探讨中药控缓释制剂多成分整体受控、同步释放的超分子机制,为中药复方缓控释制剂的研制与开发提供有益的学术参考和借鉴,进而为制备中药控缓释制剂奠定理论与技术基础。
Controlled-release preparations are an important source of innovative drugs. However, due to the complex composition of traditional Chinese medicine, physical and chemical properties of the apparent appearance of a series of key issues have not been fully clarified, so the real mature market, can reflect the essence of traditional Chinese medicine compound controlled release sustained release preparations, Limit the development of Chinese medicine controlled release formulations. Combined with the characteristics of multi-component synergistic effect of traditional Chinese medicine compound prescription, by analyzing a series of bottlenecks in the preparation process of controlled-release traditional Chinese medicine compound preparation, combined with the multi-component Chinese medicine controlled release sustained release preparation Guided by the principle of supramolecular chemistry interpretation of traditional Chinese medicine (TCM) theory, using the precise control technology of single components and applying supramolecular chemistry theory, we systematically explored the supramolecular mechanism of multi-component controlled release of traditional Chinese medicine Multi-component system in the presence of supramolecular body to explore the multi-component controlled release of Chinese herbal medicine controlled release, the simultaneous release of the super-molecular mechanism for controlled release of traditional Chinese medicine compound controlled release formulations of the research and development to provide useful academic reference and reference , And thus lay the theoretical and technical foundation for preparation of Chinese medicine controlled release sustained-release preparation.