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目的探讨血清血管内皮细胞钙黏蛋白(VEC)与糖尿病(DM)病情及与动脉粥样硬化病变程度的关系。方法 DM患者60例分为脑梗死组(CI,21例)、糖尿病肾病组(DN,18例)和无并发症糖尿病组(DM,21例);另设正常对照组(NC,20例)。用酶联免疫吸附法测定各组血清VEC浓度,并与病程、血糖水平进行相关分析。结果与正常对照组相比,DM组、DN组与CI组中血清VEC水平均明显升高(P<0.05);与DM组、DN组相比,CI组血清VEC水平显著增高(P<0.05);血清可溶性VEC水平与糖尿病患者病程和餐后血糖呈正相关(P<0.01和P<0.05)。结论 DM患者血清VEC水平与病程、餐后血糖相关,可作为预测动脉粥样硬化病变程度的危险因子。
Objective To investigate the relationship between serum vascular endothelial cell cadherin (VEC) and diabetes mellitus (DM) and the severity of atherosclerosis. Methods Diabetic patients were divided into cerebral infarction group (CI, 21 cases), diabetic nephropathy group (DN group, 18 cases) and non-diabetic group (21 cases) . Serum VEC concentration of each group was determined by enzyme-linked immunosorbent assay, and correlated with disease duration and blood glucose level. Results Compared with normal control group, serum VEC levels in DM group, DN group and CI group were significantly increased (P <0.05). Compared with DM group and DN group, serum VEC level in CI group was significantly higher (P <0.05 ). Serum soluble VEC level was positively correlated with duration of diabetes and postprandial blood glucose (P <0.01 and P <0.05). Conclusion The serum VEC level in DM patients is related to the course of disease and postprandial blood glucose, which may be used as a risk factor to predict the severity of atherosclerotic lesions.