Electrodynamic therapy (EDT) is a conceptually new cancer treatment approach recently proposed by our group.During EDT,the electro-driven catalytic reaction would occur on the surface of platinum nanoparticles (PtNPs) to produce reactive oxygen species (ROS) under the direct current (DC) or square-wave altemating current (AC) electric field.To further extend the potential of EDT,we hereby designed mesoporous silica-based nanocomposites decorated with PtNPs and loaded with anticancer drug doxorubicin (DOX) for synergistic electrodynamic-chemotherapy.Such silica-based nanocomposites could enable homogenous killing of large-sized tumors (over 500 mm3) and realize remarkable tumor destruction efficacy at a relatively low quantity of electricity.To our best knowledge,this is the first study to combine EDT and chemotherapy to develop a synergetic nanoplatform,openning a new dimension for the design of other EDT-based anticancer strategies.