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目的探讨左乙拉西坦(开浦兰)联合托吡酯治疗难治性癫痫患儿的临床疗效及其对认知功能的影响。方法 96例难治性癫痫患儿,随机分成对照组和试验组,每组48例。对照组给予托吡酯单一用药治疗,试验组给予开浦兰联合托吡酯治疗,比较两组患者的临床疗效和对认知功能的影响。结果试验组患儿的治疗总有效率、治疗1年后的发作次数及治疗3个月和治疗1年后的认知情况等均显著优于对照组,差异有统计学意义(P<0.05)。结论开浦兰联合托吡酯治疗难治性癫痫的效果较好,不良反应无明显增加,对患儿认知功能的损害相对较小,值得在临床上推广。
Objective To investigate the clinical efficacy of levetiracetam (Kepulan) combined with topiramate in the treatment of children with refractory epilepsy and its effect on cognitive function. Methods 96 cases of refractory epilepsy children were randomly divided into control group and experimental group, 48 cases in each group. The control group was treated with topiramate alone. The experimental group was given Kepulan combined with topiramate. The clinical efficacy and cognitive function of the two groups were compared. Results The total effective rate of treatment, the number of attacks after 1 year of treatment and the cognitive status after 3 months of treatment and 1 year after treatment were significantly better in the experimental group than those in the control group (P <0.05) . Conclusion Kaipulan combined with topiramate treatment of refractory epilepsy better, no significant increase in adverse reactions, the damage to children’s cognitive function is relatively small, it is worth in the clinical promotion.