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目的探讨老年2型糖尿病(T2DM)合并非酒精性脂肪肝的发生与颈动脉内膜中层厚度(IMT)的关系。方法对98例老年2型糖尿病患者,根据有无合并非酒精性脂肪肝分为合并脂肪肝组和非脂肪肝组,记录患者身高、体重、腰围、臀围,测定空腹血糖(FBG)、血总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)、APOA、APOB、空腹胰岛素(FINS)、IMT,计算体重指数(BMI)、腰臀比(WHR)、胰岛素抵抗指数(HOMA-IR)。结果老年2型糖尿病合并脂肪肝组BMI、WHR、FINS、HOMA-IR、LDL-C、TG、IMT较非脂肪肝组升高(P<0.05),而FBG、TC、HDL-C、APOA、APOB两组差别无显著性(P>0.05)。结论老年2型糖尿病合并脂肪肝组更易出现血脂异常、胰岛素抵抗及动脉粥样硬化。
Objective To investigate the relationship between carotid intima-media thickness (IMT) and the incidence of type 2 diabetes mellitus (T2DM) complicated with non-alcoholic fatty liver disease. Methods One hundred and ninety elder patients with type 2 diabetes mellitus were divided into two groups according to the presence or absence of non-alcoholic fatty liver: the height, weight, waist circumference, hip circumference, fasting blood glucose (FBG), blood Total cholesterol TC, HDL-C, LDL-C, TG, APOA, APOB, fasting insulin (FINS), IMT, body mass index BMI, WHR and HOMA-IR. Results The levels of BMI, WHR, FINS, HOMA-IR, LDL-C, TG and IMT in type 2 diabetic patients with type 2 diabetes mellitus were significantly higher than those in non-steatosis patients (P < There was no significant difference between APOB two groups (P> 0.05). Conclusion Elderly type 2 diabetic patients with fatty liver more likely to have dyslipidemia, insulin resistance and atherosclerosis.