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目的研究出现不宁腿综合征的尿毒症患者采用高通量透析技术实施治疗的临床效果。方法抽取以往在该院接受治疗的出现不宁头腿综合征的尿毒症患者84例,将其采用随机数字表法分成两组,每组42例,分别命名为对照组和治疗组。对照组实施常规血液透析治疗;治疗组实施高通量透析治疗。对比对照组与治疗组患者尿毒症不宁腿综合征治疗效果、治疗前后甲状旁腺激素和β_2-微球蛋白水平的改善幅度、治疗总时间、治疗期间出现的不良反应例数。结果治疗组治疗总有效率90.5%,高于对照组的69.1%(P<0.05);治疗前后甲状旁腺激素和β_2-微球蛋白水平的改善幅度短于对照组,差异有统计学意义(P<0.05);治疗总时间短于对照组,差异有统计学意义(P<0.05);治疗期间仅仅出现1例不良反应,少于对照组的8例(P<0.05)。结论出现不宁腿综合征的尿毒症患者采用高通量透析技术实施治疗,可以在短时间内控制症状,缩短治疗时间,减少不良反应。
Objective To study the clinical effect of high-throughput dialysis in patients with uremia of restless legs syndrome. Methods Totally 84 patients with urethral dislocation who had not treated the sciatica syndrome who had been treated in the hospital were divided into two groups (n = 42) by random number table, named as control group and treatment group respectively. The control group was treated with routine hemodialysis; the treatment group was treated with high-flux dialysis. Compare the treatment effect of patients with uremia restless legs syndrome in control group and treatment group, the improvement range of parathyroid hormone and β_2-microglobulin before and after treatment, the total treatment time and the number of adverse reactions occurred during treatment. Results The total effective rate of the treatment group was 90.5%, which was higher than 69.1% of the control group (P <0.05). The improvement of parathyroid hormone and β_2-microglobulin level before and after treatment was shorter than that of the control group (P <0.05) P <0.05). The total duration of treatment was shorter than that of the control group (P <0.05). Only one adverse reaction occurred during the treatment period, which was less than that of the control group (P <0.05). Conclusions Uremic patients with restless legs syndrome are treated by high-throughput dialysis, which can control the symptoms, shorten the treatment time and reduce the adverse reactions in a short time.