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目的 探讨苯那普利治疗慢性充血性心力衰竭 (CHF)对肾素 -血管紧张素系统和前列腺素系统的影响。方法 用放射免疫法测定 40例 CHF患者苯那普利治疗 2周前后血浆血管紧张素 (Ang )、血栓素 B2 (TXB2 )、6酮 -前列腺素 (6- keto- PGF1 a)。结果 CHF患者经苯那普利治疗 2周后血浆 Ang 、TXB2 浓度明显下降 ,6- keto-PGF1 a水平显著升高 ,TXB2 / 6- keto- PGF1 a比值明显下降 (P<0 .0 1) ;血浆 TXB2 的降低与 6- keto- PGF1 a升高呈负相关 (r=- 0 .5 9,P<0 .0 1) ;平均动脉压的下降与 6- keto- PGF1 a的升高呈负相关 (r=- 0 .41,P<0 .0 5 )。结论 苯那普利治疗 2周有利于恢复心力衰竭患者体内环境的稳定
Objective To investigate the effects of benazepril on renin-angiotensin system and prostaglandin system in patients with chronic congestive heart failure (CHF). Methods The levels of plasma angiotensin (Ang), thromboxane B2 (TXB2) and 6-keto-prostaglandin (6-keto-PGF1 a) were determined by radioimmunoassay in 40 CHF patients before and after benazepril treatment. Results After 2 weeks of treatment with benazepril, the plasma concentrations of Ang and TXB2 were significantly decreased, the level of 6-keto-PGF1 a was significantly increased and the ratio of TXB2 / 6-keto-PGF1 a was significantly decreased (P <0.01) ; The decrease of plasma TXB2 was negatively correlated with the increase of 6-keto-PGF1 a (r = -0.59, P <0.01); the decrease of mean arterial pressure and the increase of 6-keto-PGF1 a Negative correlation (r = - 0.41, P <0. 05). Conclusion Benazepril treatment for 2 weeks is conducive to the recovery of the stability of the environment in patients with heart failure