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近年来免疫细胞化学显示脊髓背角浅层(Ⅰ～Ⅱ层)内含有大量的神经递质和调质,其中大部分存在于初级传入C类纤维末梢,如P物质(SP)和降钙素基因相关肽等.应用抗体微电极技术,我们曾观察到辣椒素作为一种化学性的伤害性刺激急性处理外周神经时,可特异地兴奋C纤维引起SP在胶状质(Ⅱ层)内释放.电生理实验表明微电泳SP可兴奋背角内伤害性感受神经元.这些结果明确提示SP介导痛觉信息的传入.γ-氨基丁酸(GABA)作为一种中枢神经系统的主要抑制性递质大量分布在背角浅层.参与对脊髓痛觉的调制,基于GABA与SP在背角浅层分布的高度重迭,以及GABA受体拮抗剂Bicuculline可翻转微电泳
In recent years, immunocytochemistry showed that spinal cord dorsal horn superficial layer (Ⅰ ~ Ⅱ) contains a large number of neurotransmitters and tempering, most of which exist in primary afferent C fiber tips, such as substance P (SP) and calcium Hormone-related peptide, etc. Using antibody microelectrode techniques, we have observed that capsaicin, as a chemical nociceptive stimulus for the acute treatment of peripheral nerves, can specifically excite C-fibers to cause SP in the gel (layer II) Release.Electrophysiological experiments show that SP can excite nociceptive nociceptive neurons in the dorsal horn.These results clearly suggest that SP mediates the introduction of painful information.Gamma-aminobutyric acid (GABA) is a major central nervous system inhibitory Sexual neurotransmitters are abundantly distributed in the superficial layer of the dorsal horn, and are involved in the modulation of spinal allodynia based on the high degree of superposition of GABA and SP in the superficial layer of the dorsal horn, and the GABA receptor antagonist Bicuculline reversible microelectrophoresis