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[目的]探讨单药紫杉醇每周方案同期放疗治疗老年局部晚期肺癌的疗效。[方法]采用数字表法将80例符合条件的患者随机分为试验组和对照组,各40例。两组患者皆给予放疗,肿瘤量64~68Gy。试验组在放疗的第1d开始给予单药紫杉醇每周方案化疗,紫杉醇40mg/(m2.w),化疗后3h内放疗。化疗于放疗的第1、8、15、22、29、36、43d使用。[结果]试验组、对照组有效率分别为80.0%和50.3%(χ2=8.024,P=0.042)。试验组1、2年生存率分别为69.2%、51.4%,对照组1、2年生存率分别为43.1%、28.2%(P<0.05)。试验组白细胞下降率高于对照组(χ2=18.77,P=0.0001),其他毒副反应两组相近,均可耐受。[结论]单药紫杉醇每周方案同期放疗治疗老年局部晚期肺癌疗效较好,毒副作用较小。
[Objective] To investigate the efficacy of weekly paclitaxel weekly radiotherapy for elderly patients with locally advanced lung cancer. [Method] Eighty eligible patients were randomly divided into experimental group and control group with 40 cases in each group. Both groups were given radiotherapy, tumor volume 64 ~ 68Gy. The experimental group was given single-drug paclitaxel weekly chemotherapy, paclitaxel 40mg / (m2.w), radiotherapy within 3h after chemotherapy on the first day of radiotherapy. Chemotherapy in radiotherapy the first 1,8,15,22,29,36,43 d use. [Results] The effective rates of the experimental group and the control group were 80.0% and 50.3%, respectively (χ2 = 8.024, P = 0.042). The 1-year and 2-year survival rates of the experimental group were 69.2% and 51.4%, respectively. The 1-year and 2-year survival rates of the control group were 43.1% and 28.2%, respectively (P <0.05). The leukopenia rate in the experimental group was higher than that in the control group (χ2 = 18.77, P = 0.0001). The other toxic and side effects were similar in both groups and could be tolerated. [Conclusion] The single-drug paclitaxel weekly program with concurrent radiotherapy for advanced local advanced lung cancer has better efficacy and less side effects.