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目的探讨早产儿及其与高胆红素血症、缺氧缺血性脑病(HIE)分别或同时存在时的听力损害特点,为早期治疗干预提供依据。方法 2003年1月-2008年12月我院新生儿科住院的199例早产儿为科研对象。将199例早产儿分为单纯早产儿组,早产儿加高胆红素血症组,早产儿加HIE组,早产儿加高胆红素血症加HIE组。对每组早产儿给予听性脑干诱发电位(ABR)检测。结果早产儿ABR总的反应阈为(57.12±21.53)dBnHL,总的异常率为46.73%。当早产儿与高胆红素血症、HIE三种高危因素同时并存时,其异常发生率、重度异常发生率、平均反应阈均显著提高。结论早产儿与高胆红素血症、HIE等高危因素分别或同时并存时,听损伤的几率相应增加,听损伤的程度也随之加重,此类患儿更应及早干预、重点随访。
Objective To investigate the characteristics of hearing loss in preterm infants and their relationship with hyperbilirubinemia and hypoxic-ischemic encephalopathy (HIE) separately or simultaneously, and provide the basis for early treatment intervention. Methods From January 2003 to December 2008, 199 cases of premature infants admitted to neonatal department of our hospital were selected as research subjects. 199 premature infants were divided into simple premature children, premature children plus hyperbilirubinemia group, premature children plus HIE group, premature children plus hyperbilirubinemia plus HIE group. Each group of premature children given auditory brainstem response (ABR) detection. Results The total reaction threshold of ABR in preterm infants was (57.12 ± 21.53) dBnHL, the total abnormal rate was 46.73%. When premature children with hyperbilirubinemia, HIE three risk factors coexist at the same time, the abnormal incidence, the incidence of severe abnormalities, the average response threshold were significantly increased. Conclusions When the risk factors of premature infant, hyperbilirubinemia and HIE are respectively or simultaneously co-exist, the probability of hearing damage increases correspondingly, and the degree of hearing impairment also increases. Such children should be treated as soon as possible and followed up with high priority.