铁是一切生命体都不可缺少的必需元素,参与了氧的转运和利用以及与生命活动有关的多种酶的组成。但是,过量的铁将对机体造成各种毒性反应。因此,细胞铁稳态的维持和调节成为目前铁代谢研究方面的中心环节。机体对铁代谢的调节中铁蛋白和转铁蛋白受体在控制铁的摄取、贮存以及保持细胞内正常铁浓度的过程中起了重要的作用。现普遍认为对这两种蛋白质表达的调控是一种转录后的调节机制,该机制的核 Iron is an indispensable and indispensable element of all living things and is involved in the transport and utilization of oxygen and the composition of various enzymes involved in life activities. However, excess iron will cause various toxic reactions to the body. Therefore, the maintenance and regulation of cellular iron homeostasis become the central aspect of iron metabolism research. Regulation of iron metabolism by the body Ferritin and transferrin receptors play an important role in controlling the uptake and storage of iron and in maintaining normal intracellular iron concentrations. It is generally accepted that the regulation of the expression of these two proteins is a post-transcriptional regulatory mechanism, the mechanism of nuclear