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神经肽Y（NPY）0．2μg／kg静脉注射使毁脊髓大鼠的收缩压（SAP）、舒张压（DAP）、左室压（LVP）、左室压最大变化速率（±dP／dtmax）迅速上升，与给药前比较，有显著性差异（P<0．05和P<0．01），但持续时间较短，7min开始下降，10min即恢复正常。粉防己碱（Tet）可使以上心功能指标下降（P＜0．05和P＜0．01）。Tet、雷米普利（Ram）分别与NPY联合应用，3min时，LVP、±dP／dtmax、SAP、DAP升高，与单纯NPY组比较，无明显差别，但上升幅度不如NPY组，升高持续时间较NPY组明显缩短，5min时，以上参数迅速下降，并基本恢复至给药前的水平，与NPY组比较，有明显差异（P＜0．05），提示Tet、Ram与NPY联合应用可减弱NPY的心血管作用。
The systolic blood pressure (SAP), diastolic blood pressure (DAP), left ventricular pressure (LVP), the maximum rate of change of left ventricular pressure (± dP / dtmax) (P <0.05 and P <0.01), but the duration was short and began to decrease at 7min, and returned to normal after 10min. Tetrandrine (Tet) can make the above cardiac function decreased (P <0.05 and P <0.01). Tet and ramipril were respectively used in combination with NPY. The levels of LVP, ± dP / dtmax, SAP and DAP increased at 3min, but no significant difference compared with NPY group was observed Compared with NPY group, the above parameters decreased rapidly (P <0.05), suggesting that the combination of Tet, Ram and NPY Can weaken the cardiovascular effects of NPY.