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许多实验表明胞膜钙转运功能障碍与高血压发病密切相关,且这种障碍具有遗传倾向。程淮勇等发现有高血压病家族史儿童红细胞膜Ca~(2+),Mg~(2+)-ATP酶活性较无高血压病家族史者明显低。为探讨红细胞膜Ca~(2+),Mg~(2+)-ATP酶活性变化的原因,本实验测定了有和无高血压病家族史儿童血浆钙调素(CAM)含量。 观察对象 采用整群调查方法从北京石景山区二所小学5～6年级共262名(男115名,女147名)学生中选出有及无高血压病家族史儿童二组各15名,年龄11～13岁,男女之比
Many experiments show that the membrane calcium transport dysfunction and the incidence of hypertension are closely related, and this disorder has a genetic predisposition. Cheng Huaiyong et al found that the plasma Ca ~ (2 +) and Mg ~ (2 +) - ATPase activities of children with family history of hypertension were significantly lower than those without family history of hypertension. In order to explore the reasons for the changes of Ca ~ (2 +) and Mg ~ (2 +) - ATPase activities in erythrocyte membrane, the content of plasma calmodulin (CAM) in children with and without family history of hypertension was measured in this experiment. A total of 262 (115 males and 147 females) students from Grade 5 to Grade 6 in two primary schools of Shijingshan District of Beijing were enrolled in the study. Fifteen children with no family history of hypertension and 15 children of each age group 11 to 13 years old, the ratio of men and women