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目的:研究四种熏洗药物对伤口肉芽组织的影响。方法:以熏洗一号、洁尔阴、PP粉、生理盐水分别治疗小鼠实验性肛旁手术伤口,观察各组小鼠伤口肉芽组织中细菌数、羟脯氨酸量、术后第5天肉芽组织出现情况、7和14天肉芽组织肉眼及病理学变化。结果:与生理盐水组比熏洗一号方不能促进肉芽组织的出现,能减少肉芽组织内细菌数,增加7、14天肉芽组织内羟脯胺酸量,改善肉芽组织的质量。洁尔阴能提高14天肉芽内羟脯胺酸量,改善肉芽组织的质量。PP粉组能明显减少肉芽组织内细菌数,其余各指标与生理盐水组无显著性差异。结论:中药能提高伤口肉芽组织的质量,促进愈合。
Objective: To study the effect of four kinds of fumigation agents on wound granulation tissue. Methods: The experimental group of experimental perianal wounds were treated with Fumigation No.1, Jieeryin, PP powder and physiological saline respectively. The numbers of bacteria, hydroxyproline in the granulation tissue of mice in each group were observed, Day granulation tissue appearance, 7 and 14 days granulation tissue macroscopic and pathological changes. Results: Compared with saline group, fumigating first party can not promote the emergence of granulation tissue, reduce the number of bacteria in granulation tissue, increase hydroxyproline content in granulation tissue and improve the quality of granulation tissue in 7 and 14 days. Jieeryin can increase the amount of hydroxyproline in granulation in 14 days and improve the quality of granulation tissue. PP powder group can significantly reduce the number of bacteria in the granulation tissue, the rest of the indicators and the saline group no significant difference. Conclusion: Chinese medicine can improve the quality of wound granulation tissue and promote healing.