非抗心律失常药物的促心律失常作用常孤立发生且尚未进行详尽评价。作者仅讨论常用制剂的促心律失常作用、可能的机制及诱因。抗生素几种抗生素已表明有促心律失常作用。wharton报道2例AIDS病人,给予喷他脒后在无心脏病或非心脏因素影响时发生了尖端扭转型室速(Tdp)。其促心律失常机理可能与其结构上同普鲁卡因胺相似及其组织和心肌贮存水平高有关,重复给药可再出现,提示该作用系促心律失常性质。金刚烷胺在1例超量服用的青年妇女引起了Tdp,其机制与突触前儿茶酚胺摄取的过度抑制有 The role of non-antiarrhythmic drugs in promoting arrhythmia often occurs in isolation and has not been exhaustively evaluated. The authors only discuss the role of common agents in the promotion of arrhythmia, possible mechanisms and incentives. Several antibiotics antibiotics have been shown to promote arrhythmia. Wharton reported two cases of AIDS patients, after giving pentamidine occurred in the absence of heart disease or non-cardiac factors, the occurrence of torsades de pointes (Tdp). Its proarrhythmic mechanism may be related to its structure similar to procainamide and its high levels of tissue and myocardial storage, repeated administration can reappear, suggesting that the role of the Department of cardiac arrhythmia. Amantadine causes Tdp in one of the overdosed young women with an over-inhibition of presynaptic catecholamine uptake