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目的探讨出生顺序与肝癌发生的关系,估计环境因素与遗传因素在肝癌发生中的相对作用。方法应用Haldane-Smith法和Greenwood-Yule法对肝癌患者进行出生顺序分析。结果用Haldane-Smith法分析97例肝癌患者的出生顺序,∑6A=1542,∑χ6A=1617,C值为0.935(P>0.20);对肝癌先证者按HBsAg携带状态进行分层分析,HBsAg阳性者的C值为0.950(P>0.20),阴性者的C值为0.274(P>0.50)。用Greenwood-Yule法比较肝癌患者出生顺序的实际分布和期望分布,显示两者无明显差异,实际数与期望数的比值波动在0.78~1.38,没有随出生顺序而增加或降低的趋势;按肝癌先证者HBsAg携带状态进行分层分析,无论HBsAg阳性或阴性,其出生顺序的实际分布和期望分布均无明显差异,实际数与期望数的比值亦均无随出生顺序而增加或降低的趋势。结论洛阳市肝癌的发生可能与出生顺序无关。
Objective To investigate the relationship between birth order and the occurrence of hepatocellular carcinoma and estimate the relative role of environmental factors and genetic factors in the development of hepatocellular carcinoma. Methods Haldane-Smith method and Greenwood-Yule method were used to analyze the birth sequence of patients with liver cancer. Results The sequence of birth of 97 patients with HCC was analyzed by Haldane-Smith method. Σ6A = 1542, Σχ6A = 1617, C value was 0.935 (P> 0.20). HCC patients were stratified by HBsAg carrier status, HBsAg The positive C values were 0.950 (P> 0.20), negative C values were 0.274 (P> 0.50). The actual distribution and expected distribution of HCC patients by Greenwood-Yule method showed no significant difference between the two. The ratio of actual number to expected number fluctuated from 0.78 to 1.38, which did not increase or decrease with birth order. There was no significant difference in the actual distribution and expected distribution of the birth order regardless of the HBsAg positive or negative HBsAg status of the proband, and no increase or decrease in the ratio of the actual number to the expected number with the birth order . Conclusion The incidence of liver cancer in Luoyang may not be related to the birth order.