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本文根据１９８６－１９８７年全国统一出生缺陷监测结果，对云南昭通地区出生缺陷、围产儿死亡高发的原因进行了综合调查。通过采用沙门氏菌回复突变试验，对该地居室内空气飘尘的致突变活性进行检测，同时对食用的发芽马铃薯所含龙葵素含量进行了测定，以上两项结果均为该地出生缺陷高发的不可忽视的原因。本文还对与出生缺陷发生及围产儿死亡有关的近亲婚配及饮用水的水质改变分别作了回顾性调查及检测分析，并根据调查结果提出了预防措施。
This article based on the 1986-1987 national unified birth defects monitoring results, Zhaotong region of Yunnan birth defects, high incidence of perinatal causes were investigated. Through the use of Salmonella mutation test to test the mutagenic activity of indoor airborne dust in this habitat, the contents of solanine in edible budding potato were also tested. Both of the above results are for the reason of the high incidence of birth defects Neglected reason. This article also retrospectively investigated and analyzed the water quality changes of inbreeding and drinking water related to the birth defects and perinatal deaths respectively and put forward the preventive measures according to the survey results.