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目的研究嘧啶亚硝脲(ACNU)对脑胶质瘤术后残余组织治疗效果,分析有利预后的因素。方法选取唐山市人民医院150例确诊为脑胶质瘤患者,随机分为实验组和对照组。实验组采用ACNU于脑胶质瘤术后两周进行化疗,1次/d,2～3mg/kg。对照组患者在施行常规性开颅肿瘤切除之后,采用单纯的放射性化疗。对比两组的生存率和不良反应。结果实验组经数据统计后分析得出患者术后第一年、第三年、第五年的生存率分别是:83.31%,64.15%,31.23%,相对对照组而言,化疗组预后在术后一年时并无明显差异(P>0.05),但是患者术后3到5年存活率则存在显著差异,具有统计学意义(P<0.05)。结论术后化疗方法与病理分级是影响脑胶质瘤预后的重要因素,AVNU辅助化疗可以提高患者生存率,抑制肿瘤生长。
Objective To study the therapeutic effect of pyrimidine-nitrosourea (ACNU) on residual tissue after glioma surgery and to analyze the factors that favored prognosis. Methods 150 patients diagnosed as glioma in Tangshan People’s Hospital were randomly divided into experimental group and control group. The experimental group was treated with ACNU for two weeks after the surgery of glioma, 1 / d, 2 ~ 3mg / kg. Control group of patients after the implementation of conventional craniotomy tumor resection, the use of simple radiotherapy. The survival and adverse reactions of the two groups were compared. Results The statistical analysis of the experimental group showed that the survival rates of the first year, the third year and the fifth year were 83.31%, 64.15% and 31.23% respectively. The prognosis of the chemotherapy group was significantly higher than that of the control group There was no significant difference in the first year (P> 0.05). However, there was a significant difference in the survival rate between 3 and 5 years after operation (P <0.05). Conclusions Postoperative chemotherapy and pathological grading are important factors affecting the prognosis of glioma. AVNU adjuvant chemotherapy can improve the survival rate and inhibit tumor growth.