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目的对流行性奈瑟氏脑脊髓膜炎(简称流脑)疑似病例检测结果进行分析,为流脑监测提供依据。方法对155例流脑疑似病例进行全血培养、脑脊液培养、流脑特异性抗原、流脑DNA、急性期和恢复期IgG抗体检测。比较检测结果的阳性率。结果155例流脑疑似病例中实验室确诊79例,阳性率54.1%;其中流脑C群为77例占97.5%。密切接触者带菌129例,阳性率为8.1%;其中C群为103例占79.8%。样本和样本组合阳性率以双份血清阳性率最高,脑脊液阳性率次之,血培养阳性率最低。结论C群流脑仍然占绝对优势,密切接触者菌群与流行病例一致。考虑到快速诊断的要求,样本采集中,应以脑脊液和双份血清为主。
Objective To analyze the detection results of suspected cases of epidemic Neisseria meningitidis (referred to as meningitis), and provide evidence for the detection of meningitis. Methods The whole blood culture, cerebrospinal fluid culture, meningococcal specific antigen, meningococcal DNA, acute and recovery IgG antibodies were detected in 155 suspected cases of meningitis. Compare the positive rate of test results. Results Among 155 suspected cases of meningitis, 79 cases were confirmed by laboratory tests, the positive rate was 54.1%. Among them, 77 cases (97.5%) of meningitis C group were detected. 129 cases of close contact with carriers, the positive rate was 8.1%; of which 103 cases of C group accounted for 79.8%. The positive rate of the sample and the sample combination was highest in double seroprevalence, followed by the positive rate of cerebrospinal fluid and lowest in the blood culture. Conclusion Group C meningitis still accounted for the absolute predominance. The close contacts were consistent with epidemic cases. Taking into account the requirements of rapid diagnosis, sample collection, should be mainly cerebrospinal fluid and double serum.