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目的 :观察蝙蝠葛碱和胡椒碱对两株鼻咽癌细胞增殖的影响。方法 :用MTT法测定两种药物分别处理CNE 1、CNE 2Z细胞株 2 4、48、72h的IC50 值。结果 :蝙蝠葛碱和胡椒碱分别作用CNE 1、CNE 2Z两株细胞的IC50 值随作用时间的延长而减少 (P <0 .0 1) ,两种药物处理CNE 1细胞 2 4、48h的IC50 值均明显低于CNE 2Z细胞 (P <0 .0 1) ,蝙蝠葛碱处理两株细胞 72h的IC50 值差异显著 (P <0 .0 5 )。结论 :蝙蝠葛碱和胡椒碱对CNE 1、CNE 2Z细胞株的生长增殖呈时间依赖性抑制 ,对CNE 1细胞株的增殖抑制作用明显强于CNE 2Z细胞株
Objective: To observe the effects of dauricine and piperine on the proliferation of two nasopharyngeal carcinoma cells. Methods: The IC50 values of CNE 1 and CNE 2Z cell lines 2, 48, and 72h were determined by MTT assay. Results: The results showed that the IC50 values of both CNE 1 and CNE 2Z cells decreased with the time of action (P <0.01). The IC50 of CNE 1 and CNE 2Z cells treated with both drugs for 2 and 48 hours (P <0.01). The IC50 value of two cells treated with dauricum for 72h was significantly different (P <0.05). CONCLUSION: Both dauricine and piperine can inhibit the proliferation of CNE 1 and CNE 2Z cell lines in a time-dependent manner, and inhibit the proliferation of CNE 1 cell line significantly more than that of CNE 2Z cell line