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胰岛素样生长因子-I(IGF-I)对正常和恶性前列腺上皮细胞都是一个有力的促有丝分裂因子。循环中大多数IGF-I和IGF结合蛋白-3(IGFBP-3)结合而束缚了生物利用度。多重研究表明血清高的IGF-I和或低的IGFBP-3水平与前列腺癌的危险性有很大关系。IGF-I和IGFBP-3编码区域的多态性与增
Insulin-like growth factor-I (IGF-I) is a potent mitogen for both normal and malignant prostate epithelial cells. Binding of most IGF-I and IGF-binding protein-3 (IGFBP-3) in the circulation binds to bioavailability. Multiple studies have shown that high serum IGF-I and or low IGFBP-3 levels have a strong relationship with the risk of prostate cancer. Polymorphisms and Additions of IGF-I and IGFBP-3 Coding Regions