目的:检测肝硬化伴有不同程度肾功能损害的患者的血清C-反应蛋白(CRP)水平,探讨其在肝肾综合征(HRS)中的临床意义。方法:测定90例肝硬化病人和26例健康体健者的血清CRP水平,同时检测其肾功能。并分析CRP与肌酐清除率(Ccr)的关系。结果:CRP在肝硬化不同程度肾功能损害患者均较正常组明显升高,且随着肾功能衰竭的加重有逐渐升高的趋势,并与Ccr成负相关。结论:肝硬化患者血清CRP水平可反映肝硬化肾功能损害的程度,并有助于判断HRS病情及预后。 Objective: To detect the serum level of C-reactive protein (CRP) in cirrhotic patients with varying degrees of renal dysfunction and to explore its clinical significance in hepatorenal syndrome (HRS). Methods: Serum CRP levels were measured in 90 patients with cirrhosis and 26 healthy people, meanwhile renal function was measured. The relationship between CRP and creatinine clearance (Ccr) was analyzed. Results: CRP levels in patients with different degrees of renal damage were significantly higher than those in the normal group, and gradually increased with renal failure, and negatively correlated with Ccr. Conclusion: The level of serum CRP in patients with cirrhosis can reflect the degree of renal dysfunction in patients with cirrhosis and help to judge the condition and prognosis of HRS.