The Mesozoic intermediate-acid intrusive rocks in Tongling area can be divided into two magmatic series, namely the shoshonitic series and the high-potassium (K) calc-alkaline series. The shoshonitic series is characterized by an association of pyroxene monzodiorites+monzodiorites+quartz monzonites, the Rittmann indices of these rocks are greater than 4 (ranging from 4.2 to 5.8), the total of rare earth elements (SREE) ranges from 210?0-6 to 260?0-6, and has good relationship with gold deposits. The high-potassium calc-alkaline series is by an association of diorite+quartz monzodiorites+granodiorites, the Rittmann indices are less than 4 (1.8-3.2), SREE 130?0-6 -180?0-6, and has good relationship with copper deposits. Together with lithoenclave study, it can be concluded that the shoshonitic series magma is derived from the differentiation of the alkaline basic magma in mantle and the high-potassium (K) calc-alkaline series magma is mixture between the differentiated mantle magma and crustal magma. The Mesozoic intermediate-acid intrusive rocks in Tongling area can be divided into two magmatic series, namely the shoshonitic series and the high-potassium (K) calc-alkaline series. The shoshonitic series is characterized by an association of pyroxene monzodiorites + monzodiorites + quartz monzonites, the Rittmann indices of these rocks are greater than 4 (ranging from 4.2 to 5.8), and the total of rare earth elements (SREE) ranges from 210? 0-6 to 260? 0-6, and has good relationship with gold deposits The high-potassium calc-alkaline series is by an association of diorite + quartz monzodiorites + granodiorites, the Rittmann indices are less than 4 (1.8-3.2), SREE 130? 0-6 -180? 0-6, and has good relationship with copper deposits. Together with lithoenclave study, it can be concluded that the shoshonitic series magma is derived from the differentiation of the alkaline basic magma in mantle and the high-potassium (K) calc-alkaline series magma is mixture between the differentiated mantle magma and c rustal magma.