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目的:探讨拉莫三嗪对部分性发作癫痫患者的疗效及对认知功能及生活质量的影响。方法:选择2012年6月到2013年12月在我院接收治疗的部分性发作癫痫患者60例,按随机数字表法随机分为对照组(n=30)和治疗组(n=30);对照组患者给予卡马西平进行治疗,治疗组患者给予拉莫三嗪进行治疗。治疗20周后,对比两组患者的治疗效果、认知功能及生活质量。结果:治疗组患者的无发作率和总有效率分别为20.00%和80.00%,均显著高于对照组的6.67%和53.33%(P<0.05);治疗后治疗组患者认知功能总评分明显高于对照组,(P<0.05);治疗后治疗组患者各项生活质量评分均明显高于对照组(均P<0.05)。结论:拉莫三嗪对部分性发作癫痫患者有显著疗效,能够有效控制癫痫发作,对改善患者认知功能及生活质量有重要作用。
Objective: To investigate the effect of lamotrigine on cognitive function and quality of life in patients with partial seizures. Methods Sixty patients with partial seizures who received treatment in our hospital from June 2012 to December 2013 were randomly divided into control group (n = 30) and treatment group (n = 30) according to random number table. Patients in the control group were treated with carbamazepine, and patients in the treatment group were given lamotrigine for treatment. After 20 weeks of treatment, the therapeutic effect, cognitive function and quality of life of the two groups were compared. Results: The rate of non-attack and total effective rate in treatment group were 20.00% and 80.00% respectively, which were significantly higher than 6.67% and 53.33% in control group (P <0.05). After treatment, the total score of cognitive function in treatment group was significantly (P <0.05). After treatment, all the quality of life scores in the treatment group were significantly higher than those in the control group (P <0.05). Conclusion: Lamotrigine has a significant effect on patients with partial seizures and can effectively control seizures, which plays an important role in improving cognitive function and quality of life.