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采用手性衍生化法，实验室合成Ｌ－丝氨酸甲酯盐酸盐作为手性衍生试剂。用于萘普生和（ＲＳ）－β（６－甲氧基萘基）－２－丙酸对映异构体的柱前衍生，以酞氯化间接衍生或缩水剂Ｎ，Ｎ’．二环己基碳化二亚胺（ＤＣＣＩ）直接衍生形成酰胺非对映异构体对，然后用常规硅胶柱分离，同时利用色谱保留值规律和光谱特征吸收曲线综合进行定性分析。
Using chiral derivatization, L-serine methyl ester hydrochloride was synthesized in the laboratory as a chiral derivatization reagent. Pre-column derivatization for enantiomers of naproxen and (RS) -β (6-methoxynaphthyl) -2-propanoate, with phthalocyanine indirect derivatization or shrinkage agent N, N ’. Dicyclohexylcarbodiimide (DCCI) was directly derivatized to form amide diastereomer pairs, which were then separated on a conventional silica gel column. Qualitative analysis was carried out using the chromatographic retention law and spectral characteristic absorption curve synthesis.