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目的探讨趋化因子受体CXCR4及血管内皮生长因子VEGF在食管鳞状细胞癌组织中的表达情况及其与食管鳞癌各临床病理资料的关系。方法免疫组化S-P染色法检测85例食管癌标本中CXCR4、VEGF的表达,并对其与临床病理参数的关系进行分析。结果CXCR4、VEGF在食管鳞癌中的阳性表达率分别为45.9%、50.5%,其中有淋巴结转移组CXCR4、VEGF的表达水平均高于无淋巴结转移组。而且,CXCR4阳性表达与VEGF阳性表达呈显著正相关(P<0.05)。结论CXCR4和VEGF的表达与食管癌淋巴结转移密切相关,两者在食管癌的发生和转移过程中可能起着协调作用。
Objective To investigate the expression of chemokine receptor CXCR4 and vascular endothelial growth factor VEGF in esophageal squamous cell carcinoma and its relationship with clinicopathological data of esophageal squamous cell carcinoma. Methods The expression of CXCR4 and VEGF in 85 cases of esophageal cancer specimens was detected by immunohistochemical S-P staining. The relationship between the expression of CXCR4 and clinicopathological parameters was analyzed. Results The positive rates of CXCR4 and VEGF in esophageal squamous cell carcinoma were 45.9% and 50.5%, respectively. The expressions of CXCR4 and VEGF in lymph node metastasis group were higher than those without lymph node metastasis group. Moreover, CXCR4 positive expression was positively correlated with VEGF positive expression (P <0.05). Conclusion The expressions of CXCR4 and VEGF are closely related to the lymph node metastasis of esophageal cancer, which may play a coordinating role in the carcinogenesis and metastasis of esophageal cancer.